The role of VEGF receptors in angiogenesis; complex partnerships
Identifieur interne : 007824 ( Main/Exploration ); précédent : 007823; suivant : 007825The role of VEGF receptors in angiogenesis; complex partnerships
Auteurs : S. Cébe-Suarez [Suisse] ; A. Zehnder-Fj Llman [Suisse] ; K. Ballmer-Hofer [Suisse]Source :
- Cellular and Molecular Life Sciences [ 1420-682X ] ; 2006.
Abstract
Vascular endothelial growth factors (VEGFs) regulate blood and lymphatic vessel development and homeostasis but also have profound effects on neural cells. VEGFs are predominantly produced by endothelial, hematopoietic and stromal cells in response to hypoxia and upon stimulation with growth factors such as transforming growth factors, interleukins or platelet-derived growth factor. VEGFs bind to three variants of type III receptor tyrosine kinases, VEGF receptor 1, 2 and 3. Each VEGF isoform binds to a particular subset of these receptors giving rise to the formation of receptor homo- and heterodimers that activate discrete signaling pathways. Signal specificity of VEGF receptors is further modulated upon recruitment of coreceptors, such as neuropilins, heparan sulfate, integrins or cadherins. Here we summarize the knowledge accumulated since the discovery of these proteins more than 20 years ago with the emphasis on the signaling pathways activated by VEGF receptors in endothelial cells during cell migration, growth and differentiation.
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DOI: 10.1007/s00018-005-5426-3
PubMed: 16465447
PubMed Central: 2773843
Affiliations:
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Cébe-Suarez</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Biomolecular Research, Molecular Cell Biology, Paul Scherrer Institut, 5232 Villigen, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Biomolecular Research, Molecular Cell Biology, Paul Scherrer Institut, 5232 Villigen</wicri:regionArea><wicri:noRegion>5232 Villigen</wicri:noRegion></affiliation></author><author><name sortKey="Zehnder Fj Llman, A" sort="Zehnder Fj Llman, A" uniqKey="Zehnder Fj Llman A" first="A." last="Zehnder-Fj Llman">A. Zehnder-Fj Llman</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Biomolecular Research, Molecular Cell Biology, Paul Scherrer Institut, 5232 Villigen, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Biomolecular Research, Molecular Cell Biology, Paul Scherrer Institut, 5232 Villigen</wicri:regionArea><wicri:noRegion>5232 Villigen</wicri:noRegion></affiliation></author><author><name sortKey="Ballmer Hofer, K" sort="Ballmer Hofer, K" uniqKey="Ballmer Hofer K" first="K." last="Ballmer-Hofer">K. Ballmer-Hofer</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Biomolecular Research, Molecular Cell Biology, Paul Scherrer Institut, 5232 Villigen, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Biomolecular Research, Molecular Cell Biology, Paul Scherrer Institut, 5232 Villigen</wicri:regionArea><wicri:noRegion>5232 Villigen</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cellular and Molecular Life Sciences </title><idno type="ISSN">1420-682X</idno><idno type="eISSN">1420-9071</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract.</title><p>Vascular endothelial growth factors (VEGFs) regulate blood and lymphatic vessel development and homeostasis but also have profound effects on neural cells. VEGFs are predominantly produced by endothelial, hematopoietic and stromal cells in response to hypoxia and upon stimulation with growth factors such as transforming growth factors, interleukins or platelet-derived growth factor. VEGFs bind to three variants of type III receptor tyrosine kinases, VEGF receptor 1, 2 and 3. Each VEGF isoform binds to a particular subset of these receptors giving rise to the formation of receptor homo- and heterodimers that activate discrete signaling pathways. Signal specificity of VEGF receptors is further modulated upon recruitment of coreceptors, such as neuropilins, heparan sulfate, integrins or cadherins. Here we summarize the knowledge accumulated since the discovery of these proteins more than 20 years ago with the emphasis on the signaling pathways activated by VEGF receptors in endothelial cells during cell migration, growth and differentiation.</p></div></front><back><div1 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name="Suisse"><noRegion><name sortKey="Cebe Suarez, S" sort="Cebe Suarez, S" uniqKey="Cebe Suarez S" first="S." last="Cébe-Suarez">S. Cébe-Suarez</name></noRegion><name sortKey="Ballmer Hofer, K" sort="Ballmer Hofer, K" uniqKey="Ballmer Hofer K" first="K." last="Ballmer-Hofer">K. Ballmer-Hofer</name><name sortKey="Zehnder Fj Llman, A" sort="Zehnder Fj Llman, A" uniqKey="Zehnder Fj Llman A" first="A." last="Zehnder-Fj Llman">A. Zehnder-Fj Llman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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